This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (5)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Ronald P. Fischer, MD, PhD; Edward T. Peter, MD, PhD; John F. Mullane, MD, PhD

AMA Arch Surg. 1974;109(3):409-411.

Abstract
Stress ulcers are a frequent complication in patients with renal insufficiency. Rats were used to study the effect of renal insufficiency on restraint-induced stress ulcer formation. Acidotic, hyperkalemic renal insufficiency produced by the nephrotoxin uranyl nitrate and nonacidotic, normokalemic renal insufficiency produced by partial nephrectomy followed by internal contralateral nephrectomy enhance restraint-induced gastric erosions and ulcers. These studies demonstrate that both acute renal insufficiency with its concomitant acidosis and hyperkalemia and uremia enhance restraint-induced stress ulcer formation, possibly by impairing the normal reparative process of the gastric mucosa.

Author Affiliations
From the Department of Surgery, Albuquerque Veterans Administration Hospital, University of New Mexico School of Medicine (Drs. Fischer and Peter); and the Division of Surgery, Walter Reed Army Institute of Research, Walter Reed Army Medical Center (Dr. Mullane), Albuquerque, NM.

Footnotes
Accepted for publication Feb 11, 1974.

Reprint requests to VA Hospital, 2100 Ridgecrest Dr SE, Albuquerque, NM 87108 (Dr. Fischer).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Portal Hypertension and Gastric Lesions in the Rat
Phelps and Mullane
Arch Surg 1976;111:190-194.
ABSTRACT