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An Intensive Laboratory Investigation

Harjeet M. Singh, MD; Alfred J. Tector, MD; Robert J. Flemma, MD; Derward Lepley, Jr, MD

Arch Surg. 1975;110(11):1368-1373.

Abstract
• To better understand efficacy of topical cooling in myocardial protection, three groups of 12 dogs each were studied. Group 1 dogs had systemic cooling to 30 C; group 2 had cooling to 30 C and outside cooling of left ventricle; group 3 was cooled in the same way as group 2 was but also had inside of left ventricle topically cooled. Measurements were taken of left ventricular function curves, regional blood flow distribution to the subendocardium, sequential pH, Pco₂, Po₂, and lactate and serum glutamic oxaloacetic transaminase (SGOT) levels. Lower midseptal and subendocardial temperatures (means, 11 and 7 C, respectively) in group 3 correlated with higher survival and greater preservation of left ventricular function. Lower levels of SGOT and lactate in coronary sinus efflux, and higher regional flow to subendocardium postoperatively, also correlated with minimal evidence of subendocardial necrosis in group 3 dogs. Rapid cooling of subendocardium was noted as achieving maximum preservation of left ventricular function.

(Arch Surg 110:1368-1373, 1975)

Author Affiliations
From the Department of Thoracic and Cardiovascular Surgery, Medical College of Wisconsin, Allen Bradley Medical Research Laboratory, Milwaukee.

Footnotes
Accepted for publication June 27, 1975.

Read before the 23rd scientific meeting of the International Cardiovascular Society, Boston, June 19, 1975.

Reprint requests to 9800 W Bluemound Rd, Milwaukee, WI 53226 (Dr Singh).

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