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Seshadri Raju, MD; W. J. Gibson, MD; Bobby Heath, MD; Virginia Lockhart, PhD; Harold Conn, MD

Arch Surg. 1975;110(11):1374-1382.

Abstract
• In a study involving dogs, a coronary infusate containing a variety of substances including cardiac substrates, metabolic inhibitors, membrane stabilizers, electrolytes, and anticoagulants was evaluated in terms of protection afforded to the myocardium for up to 90 minutes of normothermic anoxic arrest. Electron microscopical studies and tissue adenosine triphosphate measurements revealed this coronary infusate to be considerably beneficial to the myocardium. Infused myocardium was better preserved compared to myocardium that was not infused or infused with two other "control" infusates. The individual components of our infusate are known cardiac preservatives. The rationale for combining a number of them in our infusate is to produce an additive or synergetic effect through beneficial intervention at several points in the cardiac metabolic cycle. This objective appears to have been fulfilled under the conditions of the present experiment.

(Arch Surg 110:1374-1382, 1975)

Author Affiliations
From the Department of Surgery, Veterans Administration Hospital and the University of Mississippi Medical Center, Jackson.

Footnotes
Accepted for publication July 18, 1975.

Read before the 23rd scientific meeting of the International Cardiovascular Society, Boston, June 19, 1975.

Reprint requests to 2500 N State St, Jackson, MS 39216 (Dr Raju).

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