This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (56)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

M. Ann Melly, PhD; H. C. Meng, MD, PhD; William Schaffner, MD

Arch Surg. 1975;110(12):1479-1481.

Abstract
• Parenteral nutrition via central venous catheterization is associated with serious risks, especially that of sepsis. Lipid emulsion (Intralipid [Sweden]), which may be administered peripherally, was evaluated for its potential to support microbial growth. Washed cultures of Staphylococcus aureus, Candida albicans, and three species of Gram-negative rods were all capable of multiplying in the emulsion at room temperature. Variations in inoculum size did not affect the growth rate. Studies comparing the emulsion to amino acid-glucose solutions (total parenteral nutrition [TPN]) confirmed other reports that TPN inhibits the growth of certain bacteria but merely retards fungal multiplication. When human serum was added to the lipid emulsion in an attempt to simulate in vivo conditions at the catheter tip, Escherichia coli was inhibited while the growth of S aureus and C albicans was unaltered.

(Arch Surg 110:1479-1481, 1975).

Author Affiliations
From the George Hunter Laboratory, Division of Infectious Diseases, Department of Medicine (Drs Melly and Schaffner) and the Department of Physiology (Dr Meng), Vanderbilt University School of Medicine, Nashville, Tenn.

Footnotes
Accepted for publication March 31, 1975.

Reprint requests to Department of Physiology, Vanderbilt University School of Medicine, Nashville, TN 37232 (Dr Meng).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Effect of 24-Hour Intravenous Tubing Set Change on the Sterility of Repackaged Fat Emulsion in Neonates
Reiter et al.
The Annals of Pharmacotherapy 2004;38:1603-1607.
ABSTRACT | FULL TEXT  

Guidelines for the Prevention of Intravascular Catheter-Related Infections
O'Grady et al.
Pediatrics 2002;110:e51-51.
ABSTRACT | FULL TEXT  

Techniques and Procedures: Using Needleless Intravenous Access Devices for Administering Total Parenteral Nutrition (TPN): Practice Update
Bliss and Dysart
Nutr Clin Pract 1999;14:299-303.
ABSTRACT  

Total Nutrient Admixtures Appear Safer than Lipid Emulsion Alone as Regards Microbial Contamination: Growth Properties of Microbial Pathogens at Room Temperature
Didier et al.
JPEN J Parenter Enteral Nutr 1998;22:291-296.
ABSTRACT  

Invited Review: Infection Control of Parenteral Nutrition Solutions
Thompson and Robinson
Nutr Clin Pract 1991;6:49-54.
ABSTRACT  

Catheter Sepsis From Infusate Contamination
Bozzetti et al.
Nutr Clin Pract 1990;5:156-159.
 

The Growth of Microorganisms in Total Parenteral Nutrition Admixtures
D'Angio et al.
JPEN J Parenter Enteral Nutr 1987;11:394-397.
ABSTRACT  

Microbial Growth Patterns in a Total Parenteral Nutrition Formulation Containing Lipid Emulsion
Gilbert et al.
JPEN J Parenter Enteral Nutr 1986;10:494-497.
ABSTRACT  

Bacterial/Fungal Growth in a Combined Parenteral Nutrition Solution
Mershon et al.
JPEN J Parenter Enteral Nutr 1986;10:498-502.
ABSTRACT  

Infection Control during Parenteral Nutrition Therapy
Williams
JPEN J Parenter Enteral Nutr 1985;9:735-746.
ABSTRACT  

Microbial Growth Comparisons of Five Commercial Parenteral Lipid Emulsions
Crocker et al.
JPEN J Parenter Enteral Nutr 1984;8:391-395.
ABSTRACT  

Gram-Negative Bacillary Sepsis Associated With Use of Lipid Emulsion in Parenteral Nutrition
MCKEE et al.
Arch Pediatr Adolesc Med 1979;133:649-650.
ABSTRACT