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Compensatory Hypertrophy of the Ileum After Gastroduodenojejunal Exclusion
M. David Tilson, MD;
Thomas Sweeney, MD;
Hastings K. Wright, MD
Arch Surg. 1975;110(3):309-312.
Abstract
One theory of compensatory hypertrophy of the gut suggests that ileal growth after jejunectomy results from exposure of the ileum to villus-enlarging factors emanating from the papilla of Vater. This hypothesis was tested by examination of the ileum after bypass of pancreatobiliary secretions to the colon. Hypertrophy of the ileum occurred after esophagoileostomy and gastroduodenojejunal exclusion, suggesting that adaptive growth of the gut depends on additional factors. There is evidence to support several theories of compensatory hypertrophy. A hypothesis seeking to reconcile the conflicting notions of intraluminal and hormonal stimuli is suggested.
Author Affiliations
From the Department of Surgery, Yale University School of Medicine, New Haven, Conn.
Footnotes
Accepted for publication Sept 3, 1974.
Read before the 59th clinical congress of the American College of Surgeons, Chicago, Oct 15, 1973.
Reprint requests to Department of Surgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510 (Dr. Tilson).
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