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Canine Gallbladder BileEffects of Proximal Gastric Vagotomy, Truncal Vagotomy, and Truncal Vagotomy With Pyloroplasty on Volume and Composition
Bruce G. Wilbur, MD;
Francisco C. Gomez, MD;
Ronald K. Tompkins, MD
Arch Surg. 1975;110(7):792-796.
Abstract
Three groups of four dogs each underwent proximal gastric vagotomy, truncal vagotomy, or truncal vagotomy with pyloroplasty. Two dogs had sham operations. Gallbladder bile was aspirated and measured. Aliquots were cultured and assayed for cholesterol, phospholipid, and bile salts initially and at subsequent laparotomies.
Both truncal vagotomy groups showed marked increases in aspirate volume at subsequent laparotomies. The sham and proximal gastric vagotomy groups showed a small initial decrease in mean aspirate volume without further significant changes. When the bile assay data were plotted on triangular coordinates, all points for all groups remained well within the area of cholesterol solubility. Nevertheless, two dogs in each truncal vagotomy group were found to have gallstones. No stones were found in the sham and proximal gastric vagotomy groups. Proximal gastric vagotomy appears to preserve fasting gallbladder bile volume and does not alter bile composition in the dog.
Author Affiliations
From the Biliary Lipid Laboratory, Department of Surgery, UCLA School of Medicine, Los Angeles.
Footnotes
Accepted for publication March 7, 1975.
Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Santa Barbara, Calif, Jan 17, 1975.
Reprint requests to Biliary Lipid Laboratory, Department of Surgery, UCLA School of Medicine, Los Angeles, CA 90024 (Drs. Wilbur and Tompkins).
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