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An Evaluation by Clearance of Xenon Xe 133 From the Canine Jejunum

Samuel E. Wilson, MD; Jonathan Hiatt; Martin Winston, MD; Edward Passaro, Jr., MD

Arch Surg. 1975;110(7):797-801.

Abstract
Clearance of a parenchymal injection of xenon Xe 133 from the jejunum was used to assess changes in tissue perfusion produced by variations in superior mesenteric artery flow resulting from partial aortic occlusion. Disappearance of xenon from submucosa and muscularis was similar and reproducible. The biexponential function of the isotope clearance exhibited a rapid initial component representing mean flow. Calculated xenon clearance rates, expressed as half-times for isotope disappearance and plotted as a function of decreasing superior mesenteric artery flow, were characteristically rapid for a broad range of superior mesenteric artery flows (90 to 600 ml/min). With reduction of superior mesenteric artery flow beyond 80 ± 10 ml/min, tissue clearance of xenon was markedly prolonged. Adequate perfusion of the vascular compartments of the small bowel as measured by xenon clearance was maintained until 80% reduction of superior mesenteric artery flow.

Author Affiliations
From the surgical (Drs. Wilson and Passaro), nuclear medicine (Dr. Winston), and research (Mr. Hiatt) services, VA Wadsworth Hospital Center, and the departments of surgery (Dr. Passaro) and medicine (Dr. Winston), UCLA School of Medicine, Los Angeles.

Footnotes
Accepted for publication Feb 11, 1975.

Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Santa Barbara, Calif, Jan 17, 1975.

Reprint requests to VA Wadsworth Hospital Center, Los Angeles, CA 90073 (Dr. Wilson).

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ABSTRACT