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A New Technique for in Vivo Use

Akio Wakabayashi, MD; Yoshimasa Nakamura, MD; Telford Woolley, MD; Paul J. Mullin; Hideo Watanabe; Takashi Ino, MD; John E. Connolly, MD

Arch Surg. 1975;110(7):802-805.

Abstract
Newly developed all solid state catheter oxygen pressure (Po₂) and pH electrodes were evaluated in dogs in respiratory acidosis and hemorrhagic shock. The electrodes were inserted into the blood vessels and thigh muscle by a percutaneous puncture technique.

In animals with respiratory acidosis, arterial, venous, and intramuscular pH decreased in parallel as arterial carbon dioxide pressure (Pco₂) increased. During severe acidosis, arterial and venous Po₂ did not change appreciably, but intramuscular Po₂ decreased moderately, indicating decreased tissue perfusion.

In animals with hemorrhagic shock, intramuscular Po₂ decreased in proportion to the blood loss, whereas the reduction in intramuscular pH and blood pressure lagged behind blood loss. A similar finding was observed during reinfusion of shed blood in surviving animals. In the animals that died, intramuscular Po₂ and pH remained low after the reinfusion of all shed blood, although arterial blood pressure did return to base line levels.

Author Affiliations
From the Department of Surgery, University of California at Irvine.

Footnotes
Accepted for publication Feb 11, 1975.

Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Santa Barbara, Calif, Jan 17, 1975.

Reprint requests to Department of Surgery, University of California, Irvine, CA 92664 (Dr. Wakabayashi).

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