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A Pathologic Reassessment

David Murray, MB, ChB, MRCPath; Andrew Hreno, MD, FRCS (C); James Dutton, MD; Lawrence G. Hampson, MD, FRCS (C)

Arch Surg. 1975;110(8):908-913.

Abstract
One hundred forty-eight cases of colon carcinoma were subjected to further pathologic study. Survival was correlated with stage and grade of the tumor and with the number of involved lymph nodes. In addition, cases were assessed as to the extent of local chronic inflammatory reaction about the lesion and the degree of sinus histiocytosis in draining lymph nodes.

A correlation was possible between grading, staging, extent of lymph node involvement, and survival. A substantial difference in five-year survival was shown when local inflammatory reaction was present and when sinus histiocytosis was observed. The presence of both of these factors further improved survival.

An adequate evaluation of these factors, both individually and in combination, should improve our ability to assess prognosis in colon cancer.

Author Affiliations
From the departments of surgery (Drs. Hreno, Dutton, and Hampson) and pathology (Dr. Murray), Montreal General Hospital and McGill University, Montreal.

Footnotes
Accepted for publication March 14, 1975.

Read before the 32nd annual meeting of the Central Surgical Association, Chicago, Feb 28, 1975.

Reprint requests to Department of Pathology, Montreal General Hospital, Montreal, Quebec, H3G 1A4 Canada (Dr. Murray).

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