This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (41)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Joel B. Freeman, MD; Lewis D. Stegink, PhD; Paul D. Meyer, MD; Robert G. Thompson, MD; Lawrence DenBesten, MD

Arch Surg. 1975;110(8):916-921.

Abstract
We tested the hypothesis that during infusion of amino acids without dextrose, there is less insulin stimulation, which, in turn, permits lipolysis. The results suggest that dextrose infusion stimulates insulin and inhibits lipolysis. During administration of crystalline amino acids without dextrose, nitrogen balance improved substantially from control values obtained during dextrose infusion, while the level of serum-free fatty acids and ketone bodies rose and that of serum immunoreactive insulin fell. Infusion of amino acids at 1.7 gm/kg appeared slightly more efficient than infusion at 1.0 gm/kg and did not stimulate insulin or inhibit lipolysis. Protein sparing may be useful in certain specific clinical situations. However, the results must be interpreted cautiously, primarily because it is difficult to establish the relationship between improvement in nitrogen balance and the derived clinical benefit. Absolute proof of the efficacy of this technique awaits further studies using indexes that more accurately measure protein synthesis.

Author Affiliations
From the departments of surgery (Drs. Freeman and DenBesten), biochemistry and pediatrics (Dr. Stegink), and pediatric endocrinology (Dr. Thompson), University of Iowa College of Medicine, and the Veterans Administration Hospital (Dr. Meyer), Iowa City.

Footnotes
Accepted for publication March 14, 1975.

Read before the 32nd annual meeting of the Central Surgical Association, Chicago, Feb 28, 1975.

Reprint requests to Department of Surgery, University Hospitals, University of Iowa, Iowa City, IA 52242 (Dr. Freeman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Effect of Major Thermal Injury on Plasma Ketone Body Levels
Abbott et al.
JPEN J Parenter Enteral Nutr 1985;9:153-158.
ABSTRACT  

Peripheral Vein Complications in Patients Receiving Amino Acid/ Dextrose Solutions
Massar et al.
JPEN J Parenter Enteral Nutr 1983;7:159-162.
ABSTRACT  

Energy and the Maintenance of the Body Cell Mass
Moore
JPEN J Parenter Enteral Nutr 1980;4:228-260.
 

Metabolism of Amino Acids After Trauma
Tweedle
JPEN J Parenter Enteral Nutr 1980;4:165-172.
 

Intravenous Protein-sparing Therapy in Patients with Gastrointestinal Disease
Greenberg and Jeejeebhoy
JPEN J Parenter Enteral Nutr 1979;3:427-432.
ABSTRACT  

Factors Determining Peripheral Vein Tolerance to Amino Acid Infusions
Gazitua et al.
Arch Surg 1979;114:897-900.
ABSTRACT  

Current Status of Hyperalimentation
King
Arch Otolaryngol Head Neck Surg 1979;105:369-372.
ABSTRACT  

Effect of Total Parenteral Nutrition with Cycling on Essential Fatty Acid Deficiency
Mascioli et al.
JPEN J Parenter Enteral Nutr 1979;3:171-173.
 

Protein-Sparing Therapy During Pneumococcal infection in Rhesus Monkeys
Wannemacher et al.
JPEN J Parenter Enteral Nutr 1978;2:507-518.
ABSTRACT  

Protein-Sparing in Cystectomy Patients
Hensle
JPEN J Parenter Enteral Nutr 1978;2:519-524.
ABSTRACT  

Pathogenesis and Frequency of Essential Fatty Acid Deficiency During Total Parenteral Nutrition
CONNOR
ANN INTERN MED 1975;83:895-896.
ABSTRACT