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Results of a Prospective, Randomized Evaluation of Early Postoperative Parenteral Nutrition

Ronald M. Abel, MD; Josef E. Fischer, MD; Mortimer J. Buckley, MD; G. Octo Barnett, MD; W. Gerald Austen, MD

Arch Surg. 1976;111(1):45-50.

Abstract
• A randomized evaluation of 44 malnourished patients, wherein 24 were used as controls and 20 received immediate postoperative parenteral hyperalimentation, indicated that five days of nutritional therapy had no notable effect on the morbidity and mortality experienced by the malnourished patients, in comparison to a third, nonmalnourished group of similar patients. Although central venous nutrition was safely administered without complications immediately after cardiac operations, clinical efficacy of this therapy could not be demonstrated. The inability to establish a dose-response relationship, and hence administer the "optimum" amount of nutrients, may have accounted for the negative results reported. Although preoperative malnutrition is associated with a poorer result after cardiac surgery, postoperative repletion of nutrients appears to be ineffective in reversing this relationship.

(Arch Surg 111:45-50, 1976)

Author Affiliations
From the hyperalimentation and surgical cardiovascular units (Drs Abel, Fischer, Buckley, and Austen), and the Laboratory of Computer Sciences (Dr Barnett), Massachusetts General Hospital; and the Department of Surgery, Harvard Medical School, Cambridge, Mass. Dr Abel is now with the New York Hospital-Cornell Medical Center.

Footnotes
Accepted for publication July 8, 1975.

Reprint requests to the New York Hospital-Cornell Medical Center, 525 E 68th St, New York, NY 10021 (Dr Abel).

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