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Creatine Phosphokinase Release as a Measure of Tourniquet Effect on Skeletal Muscle
David Chiu, MD;
Hsueh Hwa Wang, MD;
Marvin Richard Blumenthal, MD
Arch Surg. 1976;111(1):71-74.
Abstract
• In anesthetized dogs, a pneumatic tourniquet was applied to a hind limb for one, two, or three hours. Resultant ischemic damage to skeletal muscle was assessed by creatine phosphokinase (CPK) levels in the femoral venous blood of the experimental limb after the tourniquet was released. The CPK levels did not rise after release of one-hour occlusion in three experiments. The elevation of CPK values was demonstrated after occlusion for two hours in three of four experiments, and after occlusion of three hours in all four experiments. When a three-hour occlusion was interrupted for 15 minutes after each hour in three experiments, elevation of CPK levels was minimal or absent. Thus, skeletal muscle injury, as measured by the level of venous CPK elevation, becomes apparent after two to three hours of occlusion and can be prevented by short periods of recirculation.
(Arch Surg 111:71-74, 1976)
Author Affiliations
From the Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York. Dr Chiu is now with the Department of Surgery, Washington University School of Medicine, St Louis.
Footnotes
Accepted for publication May 22, 1975.
Read in part before the 57th annual meeting of the Federation of American Societies for Experimental Biology, Atlantic City, NJ, April 16, 1973.
Reprint requests to Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, NY 10032 (Dr Wang).
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