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What Is Its Clinical Significance?

K. Venkateswara Rao, MD; Edwin J. Smith, MD; J. Wesley Alexander, MD; James P. Fidler, MD; Seshagiri R. Pemmaraju, MD; Victor E. Pollack, MD

Arch Surg. 1976;111(10):1086-1092.

Abstract
• Detailed analysis of the clinical data and autopsy material of 100 consecutive renal transplant recipients revealed significant thromboembolic disease in 25 patients and a total of 41 complications. In six of them, thromboembolism was associated with sepsis. Nine patients died (20% of total number of deaths) due to a primary thromboembolic event. The incidence of pulmonary embolism was 14%; myocardial infarction, 3%; cerebrovascular disease, 4%; renal artery thrombosis, 2%; renal vein thrombosis, 3%; thrombophlebitis/deep vein thrombosis, 13%; and miscellaneous, 2%.

The incidence of thromboembolism was higher in patients older than 40 years of age (P =.02) and during the earlier months after transplantation. We summarize the general incidence and mortality related to thromboembolism and discuss the factors predisposing the graft recipient to thromboembolic disease. Prevention and therapy of this complication should decrease the morbidity and mortality in graft recipients and enhance the success of renal transplantation.

(Arch Surg 111:1086-1092, 1976)

Author Affiliations
From the departments of medicine, Division of Nephrology (Drs Rao, Smith, and Pollack), surgery, Division of Transplantation (Drs Alexander and Fidler), and pathology (Dr Pemmaraju), University of Cincinnati Medical Center.

Footnotes
Accepted for publication June 17, 1976.

Reprint requests to Division of Nephrology (RKDP), Department of Medicine, Hennepin County Medical Center, 701 Park Ave S, Minneapolis, MN 55415 (Dr Rao).

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