Effect of glucagon on hepatic circulation in the pig
B. Lindberg and N. Darle
The effect of intravenous injection of 50 mug/kg of glucagon on the hepatic
circulation of the pig was studied in 12 animals. Glucagon caused an
arterial pressure reduction of 11 mm Hg after two minutes and 7 mm Hg after
ten minutes. The portal pressure and blood flow were not altered. The
superior mesenteric arterial flow decreased by 12%. The hepatic arterial
blood flow increased by 80% after two minutes and by 58% after ten minutes.
There was no difference in response when anesthesia was achieved with small
intravenous doses of thiopental (Pentothal) sodium or 70% nitrous oxide in
oxygen and tubocurarine chloride.