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Gastric Acid Secretion and Acute Gastroduodenal Disease After Burns
MAJ Albert J. Czaja, MC;
LTC Joseph C. McAlhany, MC;
COL Basil A. Pruitt, Jr, MC
Arch Surg. 1976;111(3):243-245.
Abstract
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• Total titratable acidity of fasting gastric secretion was determined in 34 hemodynamically stable patients within five days after burn. Acid output was not predictive of disease; acute duodenal ulcers, however, were not discovered in patients with acid secretion of less than 3.11 mEq/hr. Patients with both gastric and duodenal disease secreted significantly (P <.05) more acid than patients without duodenal involvement and complications were more likely to develop, especially from acute ulcerations. Hemorrhage or perforation occurred in nine patients whose acid output was significantly (P <.05) greater than that of asymptomatic patients. Duodenal regulation and neutralization of acid secretion may be impaired in patients with early duodenal injury, resulting in a relative increase in acid output and enhanced potential for complications. A controlled evaluation of antacid therapy in the prevention of disease complications seems justified in these patients.
(Arch Surg 111:243-245, 1976)
Author Affiliations
USA; USA; USA
From the US Army Institute of Surgical Research, Brooke Army Medical Center, Fort Sam Houston, Tex. Dr Czaja is presently with the Mayo Clinic, Gastroenterology Division, Rochester, Minn.
Footnotes
Accepted for publication Nov 13, 1975.
The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.
Reprint requests to Library Branch, US Army Institute of Surgical Research, Brooke Army Medical Center, Fort Sam Houston, TX 78234.
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