 |
|
Total Body Washout for the Treatment of Endotoxin ShockAn Experimental Study
Yoshimasa Nakamura, MD;
Akio Wakabayashi, MD, DMS;
Telford Woolley, MD;
Paul Mullin;
Yukio Ito, MD;
John E. Connolly, MD
Arch Surg. 1976;111(7):783-786.
Abstract
| |
• In order to study the therapeutic effects of total body washout (TBW) in experimental endotoxin shock, we used the following procedure. Seventeen rabbits (controls) received Escherichia coli endotoxin (5 mg/kg) intravenously and were observed for 12 hours. Shock developed in 14 rabbits; they died in 5.2 ±1.0 (mean ± SD) hours, with a survival rate of 18%.
Seventeen rabbits were subjected to TBW only. Muscle temperature was lowered to 25 C with a pump oxygenator circuit and the animals were exsanguinated. After residual blood was flushed out with cold, lactated Ringer solution, the animals were rewarmed with another circuit that was primed with homologous blood. Fourteen animals survived (82%).
Two hours after E. coli endotoxin was injected intravenously, 17 animals were treated with TBW. The survival rate (53%) of this group was significantly higher than in the control group (18%) (P <.005). Eight nonsurvivors showed hypotension and acidosis even after TBW treatment, thus indicating the irreversibility of their endotoxin shock.
This study indicates that endotoxin shock may be reversed by TBW if it is instituted before irreversible cellular damage.
(Arch Surg 111:783-786, 1976)
Author Affiliations
From the Department of Surgery, University of California at Irvine.
Footnotes
Accepted for publication March 5, 1976.
Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Newport Beach, Calif, Jan 16, 1976.
Reprint requests to Department of Surgery, University of California at Irvine, Irvine, CA 92717 (Dr Connolly).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
