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Reinhard Bittner, MD; Hans-Günter Beger, MD; Ernst Kraas, MD; Harald Gögler, MD

Arch Surg. 1976;111(8):850-853.

Abstract
• In peripheral and portal venous blood, the immunoreactive insulin (IRI) and glucose levels in response to orally and intravenously administered glucose were measured in 14 patients with selective gastric vagotomy and pyloroplasty (SGV+P) and in 17 control subjects with other abdominal surgery.

After intravenously administered glucose, the insulin and the glucose levels were nearly identical in both groups. After orally administered glucose, there were remarkable differences. Despite their early postoperative situations, and in contrast to the control patients, the SGV+P subjects showed no hyperglycemia. The measurements of IRI in the portal vein suggested that in SGV+P patients, the response of the islet cells is accelerated.

In patients with SGV+P, the release of an insulinotropic intestinal factor and the preserved vagal innervation of the pancreas may be responsible for the accelerated insulin response and the undisturbed glucose tolerance.

(Arch Surg 111:850-853, 1976)

Author Affiliations
From the Department of Surgery, Klinikum Charlottenburg, Free University of Berlin.

Footnotes
Accepted for publication Feb 24, 1976.

Read in part before the winter meeting of the British Surgical Research Society, London, 1975.

Reprint requests to Department of Surgery, Klinikum Charlottenburg, Free University of Berlin, D-1000 Berlin 19, Spandauer Damm 130, W Germany (Dr Bittner).

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