 |
|
A Trial of Cephalothin Sodium in Colon Surgery to Prevent Wound Infection
Jonathan G. W. Burdon, MB;
Peter J. Morris, MD, PhD;
Philip Hunt, MB;
James M. Watts, MB
Arch Surg. 1977;112(10):1169-1173.
Abstract
• A double-blind trial of preoperative and perioperative cephalothin sodium in patients undergoing colonic surgery was carried out to test the value of this drug in reducing wound infection rates. Two studies were performed. In the first trial, 1 gm of cephalothin sodium or a placebo was given intravenously at the beginning of operation, and 1 gm one hour later. In the second trial, the dose of cephalothin or placebo was increased to 2 gm. There was no significant reduction in wound infections in either study in the groups receiving cephalothin, although over two thirds of the organisms cultured from the infected wounds were sensitive to cephalothin. It is suggested that meticulous attention to technique to avoid gross contamination remains the most important factor in the prevention of wound infections after colon surgery.
(Arch Surg 112:1169-1173, 1977)
Author Affiliations
From the Royal Melbourne Hospital (Dr Burdon) and the Departments of Surgery, University of Melbourne (Dr Morris) and Monash University and Prince Henry's Hospital (Drs Hunt and Watts), Melbourne. Dr Morris is presently with the University of Oxford, England; Dr Watts is presently with Flinders Medical School, Adelaide, Australia.
Footnotes
Accepted for publication May 12, 1977.
Reprint requests to Nuffield Department of Surgery, University of Oxford, Radcliffe Infirmary, Oxford, England (Dr Morris).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Antibiotic Pharmacokinetics in Surgery
Fry and Pitcher
Arch Surg 1990;125:1490-1492.
ABSTRACT
Efficacy of Oral and Systemic Antibiotic Prophylaxis in Colorectal Operations
Condon et al.
Arch Surg 1983;118:496-502.
ABSTRACT
Antibiotic Activity in Surgical Incisions: The Basis for Prophylaxis in Selected Operations
Polk et al.
JAMA 1980;244:1353-1354.
ABSTRACT
|
