Coagulation abnormalities in patients with arterial, venous, and combined arterial and venous thromboses

G. J. Collins, N. M. Rich, S. Scialla, C. A. Andersen and P. T. McDonald

Thrombotic disorders are much more common than hemorrhagic disorders. Nonetheless, most knowledge of coagulation relates to the hemorrhagic disorders. We have done extensive coagulation evaluations in patients with arterial thromboses only, venous thromboses only, and in patients with combined arterial and venous thromboses. Prominent abnormalities in platelet aggregation, factors VIII, IX, and XI levels, and fibrinogen were noted in all groups. These types of studies should eventually lead to a fuller understanding of thrombotic disorders.