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Henry T. Lynch, MD; Randall E. Harris, PhD; Wadi A. Bardawil, MD; Patrick M. Lynch, JD; Hoda A. Guirgis, PhD; Milton J. Swartz, MD; Jane F. Lynch, RN

Arch Surg. 1977;112(2):170-174.

Abstract
• A family with site-specific colon cancer and discrete adenomatous colon polyps in certain members has provided a prototype for the study and clinical management of hereditary cancer. Analysis of this kindred showed an autosomal dominant mode of inheritance, early onset of cancer with predilection for the right colon, and frequent extraprimary cancers of the colon. Knowledge of these phenomena are critical to the management of this hereditary cancer syndrome.

On our recommendation, two brothers of the family who were treated for colon cancer by hemicolectomy underwent prophylactic total colectomy. The resected colon from one of these patients had an occult adenocarcinoma in a villoglandular polyp.

(Arch Surg 112:170-174, 1977)

Author Affiliations
From the Departments of Preventive Medicine (Drs Lynch, Harris, Guirgis, and Swartz, and Mr Lynch, and Ms Lynch) and Pathology (Dr Bardawil), Creighton University School of Medicine, Omaha.

Footnotes
Accepted for publication Sept 20, 1976.

Reprint requests to Department of Preventive Medicine, Creighton University School of Medicine, 2500 California St, Omaha, NE 68178 (Dr Lynch).

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