Progesterone receptor in cystosarcoma phyllodes
B. R. Rao and J. S. Meyer
A specific receptor for progesterone has been found in a cystosarcoma
phyllodes, as determined by charcoal adsorption and sucrose gradient
analysis. Similar assays for estrogen receptors were negative. The tumor
consisted almost entirely of stroma that contained the progesterone
receptors. The epidemiology and natural history of cystosarcoma do not
strongly support the hypothesis that it is controlled by female sex
hormones, but the presence of the progesterone receptors suggests that some
cystosarcomas are hormonally regulated, and thus may be responsive to
therapeutic hormonal manipulation.
