Vitamin requirements in patients receiving total parenteral nutrition
G. E. Nichoalds, H. C. Meng and M. D. Caldwell
This study represents an initial attempt to define intravenous vitamin
requirements in adult patients receiving total parenteral nutrition (TPN).
We have investigated two different vitamin formulations for their ability
to maintain normal circulating blood levels of vitamins A, C, E, B12, folic
acid and riboflavin. Administration of 1.1 ml of Multi-Vitamin Infusion
(MVI) solution supplemented with 100 microgram of folic acid, 10 microgram
of vitamin b12, and 100 mg of vitamin C, per liter of TPN infusate
(patients received an average of about 3 liters/day), maintained normal or
higher than normal levels of vitamins C, B12, and riboflavin, but resulted
in less-than-normal levels of vitamins A, E, and folic acid. Increasing the
amount of MVI to 1.4 ml and the folic acid to 200 microgram, and decreasing
the ascorbic acid to 70 mg and vitamin B12 to 5 microgram/liter of TPN
infusate, resulted in normal blood levels of all tested vitamins within two
weeks after initiating TPN therapy, and normal blood levels were then
maintained at this dosage for additional periods of time up to three weeks.