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Influence of Aspirin and Warfarin Sodium

Edward W. Friedman, MD; Howard A. Frank, MD; Ronald Ponn, MD

Arch Surg. 1977;112(9):1072-1074.

Abstract
• Venous autografts were prepared in jugular veins of rabbits as a test model to determine the usefulness of antiplatelet and anticoagulant agents (aspirin and warfarin sodium) alone or in combination for maintaining patency in the reconstruction of small veins. Graft patency was determined by periodic venography and postmortem examination. The grafts clotted in all of the untreated controls, five of six animals receiving aspirin, and three of four receiving warfarin, but in none of the animals receiving the combination of aspirin and warfarin.

(Arch Surg 112:1072-1074, 1977)

Author Affiliations
From the Kirstein Laboratory for Surgical Research, Beth Israel Hospital, and the Department of Surgery, Harvard Medical School, Boston.

Footnotes
Accepted for publication April 14, 1977.

Reprint requests to 330 Brookline Ave, Boston, MA 02215 (Dr Friedman).

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