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Pathophysiological Basis

Jean Davignon, MD, MSc, FRCP(C)

Arch Surg. 1978;113(1):28-34.

Abstract
• A detailed analysis of the multifactorial pathogenesis of atherosclerosis, including endothelial injury, proliferation of intimal smooth muscle cells, the role of the platelet, the role of cholesterol as raw material and irritant, the influence of inflammation, and the participation of lysosomal components, is presented.

(Arch Surg 113:28-34, 1978)

Author Affiliations
From the Department of Lipid Metabolism and Atherosclerosis Research, Clinical Research Institute of Montreal, the Section of Vascular Medicine, Hôtel-Dieu Hospital of Montreal, and the Faculty of Medicine, University of Montreal.

Footnotes
Accepted for publication July 1, 1977.

Reprint requests to 110 Pine Ave W, Montreal, Quebec, H2W 1R7, Canada.

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