This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal

Vikrom S. Sottiurai, MD, PhD; William J. Fry, MD; James C. Stanley, MD

Arch Surg. 1978;113(11):1280-1288.

Abstract
• Ultrastructural characteristics of 20 dysplastic human renal arteries were documented. Loss of smooth muscle with collection of fibrous connective tissue predominated in medial fibrodysplasia, whereas excessive accumulations of elastic fibrils typified perimedial dysplasia. Myofibroblasts were a unique feature of both forms of arterial dysplasia. These modified smooth muscle cells seemed to be the source of abnormal connective tissue synthesis. Transformation of medial smooth muscle cells to myofibroblasts represented a morphologic continuum. Intramedial vasa vasorum were often isolated from surrounding cellular elements by unusual amounts of mural ground substances. The results of this study lend further support to the hypothesis that ischemia and direct physical forces effect hormonally altered cells in the pathogenesis of arterial dysplasia.

(Arch Surg 113:1280-1288, 1978)

Author Affiliations
From the Peripheral Vascular Surgery Service, Department of Surgery, University of Michigan Medical School, Ann Arbor.

Footnotes
Accepted for publication July 24, 1978.

Presented at the 26th meeting of the International Cardiovascular Society, Los Angeles, June 23, 1978.

Reprint requests to 1405 E Ann St, Ann Arbor, MI 48109 (Dr Sottiurai).

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Myofibroblasts in Palatal Wound Healing: Prospects for the Reduction of Wound Contraction after Cleft Palate Repair
van Beurden et al.
JDR 2005;84:871-880.
ABSTRACT | FULL TEXT  

Fatal Mesenteric Fibromuscular Dysplasia: A Case Report and Review of the Literature
Guill et al.
Arch Intern Med 2004;164:1148-1153.
ABSTRACT | FULL TEXT  

Communications to the Editor and Clinical Case Reports: Fibromuscular Hyperplasia of Subclavian Artery Histologic and Ultrastructural Study: A Case Report
Cifiello et al.
VASC ENDOVASCULAR SURG 1986;20:181-187.
ABSTRACT  

Fibromuscular Hyperplasia of the Brachial Artery Failure of Calcium Antagonist Therapy
Olson et al.
ANGIOLOGY 1984;35:790-796.
ABSTRACT  

Carotid Endarterectomy: Emphasis on Necessity of Long-Term Postoperative Evaluation
Sauer and Almond
VASC ENDOVASCULAR SURG 1980;14:338-345.
ABSTRACT