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Radiotherapy Combined With Curative SurgeryIts Use as Therapy for Carcinoma of the Sigmoid Colon and Rectum
Marvin M. Romsdahl, MD, PhD;
H. Rodney Withers, MD, PhD
Arch Surg. 1978;113(4):446-453.
Abstract
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• Local recurrence rates for colorectal carcinoma occur in the range from 20% to 35%. For this reason, postoperative radiotherapy was evaluated as a measure to achieve local disease control in the pelvis. Patients with tumors penetrating the entire bowel wall or with regionally involved lymph nodes received approximately 5,000 rads over a six-week period that commenced three to six weeks after surgery. Sixty-two patients treated by this method are compared with 168 patients treated without adjunctive radiotherapy. Five local recurrences occurred in the group receiving radiotherapy; a reduced incidence compared to the group managed by surgery alone. Complications attributable to radiotherapy included radiation enteritis and bowel obstruction. Measures to minimize complications with this combined approach have been identified. Surgery followed by adjuvant radiotherapy may be performed with an acceptable complication rate and this appears promising in reducing local recurrence of carcinoma of the sigmoid colon and rectum.
(Arch Surg 113:446-453, 1978)
Author Affiliations
From the Departments of Surgery (Dr Romsdahl) and Radiotherapy (Dr Withers), the University of Texas System Cancer Center, and the M. D. Anderson Hospital and Tumor Institute, Houston.
Footnotes
Accepted for publication Dec 12, 1977.
Read before the 85th annual meeting of the Western Surgical Association, Las Vegas, Nov 15, 1977.
Reprint requests to Department of Surgery, M. D. Anderson Hospital, 6723 Bertner Ave, Houston, TX 77030 (Dr Romsdahl).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Hyperthermic Pelvic Isolation-Perfusion in the Treatment of Refractory Pelvic Cancer
Wile and Smolin
Arch Surg 1987;122:1321-1325.
ABSTRACT
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