This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal

Lawrence B. Langsam, MD; Gerald Fine, MD; Joseph L. Ponka, MD

Arch Surg. 1978;113(4):473-476.

Abstract
• During the past ten years, the histiogenesis of malignant histiocytomas and a group of related benign and malignant lesions have been the source of speculation. Although of heterogeneous histological appearance, it is believed that there is a common cell of origin for these neoplasms—the histiocyte. From 1966 to 1974,16 patients were encountered who had neoplasms that fell into the general group of malignant histiocytomas. These tumors were variously located in the extremities, head, chest wall, retroperitoneum, lung, spermatic cord, and lower abdomen.

Surgical treatment included radical amputations, wide local excision, pulmonary lobectomy, and nephrectomy. Cobalt therapy and chemotherapy with vincristine sulfate, cyclophosphamide, doxorubicin hydrochloride, and chlorambucil were also used.

Ten of 16 patients are alive after treatment, two are alive with metastatic disease, but four have died of malignant disease.

(Arch Surg 113:473-476, 1978)

Author Affiliations
From the Department of Surgery, St Vincent Charity Hospital, Cleveland (Dr Langsam); the Department of Anatomical Pathology (Dr Fine) and Surgery (Dr Ponka), Henry Ford Hospital, Detroit; and the Department of Surgery, University of Michigan, Ann Arbor (Dr Ponka).

Footnotes
Read before the 85th Annual Meeting of the Western Surgical Association, Las Vagas, Nov 15, 1977.

Reprint requests to Department of Surgery, St Vincent Charity Hospital, 2351 E 22nd St, Cleveland, OH 44115 (Dr Langsam).