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Elpidio C. Mariano, MD; John H. Landor, MD

Arch Surg. 1978;113(5):611-614.

Abstract
• Eight dogs, four with intact vagi and four with vagotomy, were studied to see if the gastric secretory effect of intravenously administered L-amino acids is mediated by a gastrointestinal (GI) hormone or hormones. Intravenous infusion of amino acids produced a significant secretory response in denervated and in innervated stomachs. When the known sites of formation of GI hormones were removed by resection of antrum, duodenum, pancreas, jejunum, ileum, and colon, the gastric stimulatory effect of amino acids was not changed significantly in denervated stomachs but was greatly increased in innervated stomachs. We conclude that amino acids have a direct effect on parietal cell secretion that is not dependent on the intermediary release of a stimulatory hormone, and that evisceration enhances this effect in dogs with intact vagi.

(Arch Surg 113:611-614, 1978)

Author Affiliations
From the Department of Surgery, College of Medicine and Dentistry of New Jersey Rutgers Medical School, Piscataway, NJ.

Footnotes
Accepted for publication Oct 20, 1977.

Read in part at the 12th Congress, European Society for Surgical Research, Warsaw, April 27, 1977.

Reprint requests to PO Box 101, Piscataway, NJ 08854 (Dr Landor).

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