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Its Effects on the Healing of Colonic Anastomoses

Viratana Charoenkul, MD; A. James McElhinney, MD; W. John B. Hodgson, MS, FRCS

Arch Surg. 1978;113(5):618-620.

Abstract
• Preoperative preparation of rats with lactulose, 2.5 ml/kg of a 52.5% w/w solution, for two days resulted in increased bursting pressure and bursting wall tension of low colonic anastomoses three days postoperatively when compared with unprepared controls (85.8, viz, 36.1 mm Hg and 0.55, viz, 0.19 dynes/cm x 10^–5). After seven days, there was no appreciable difference in the rats with colonic acidification and in the controls.

(Arch Surg 113:618-620, 1978)

Author Affiliations
From the Departments of Surgery, Veterans Administration Hospital (Drs Charoenkul, McElhinney, and Hodgson), Bronx, NY, and the Mount Sinai School of Medicine, City University of New York (Drs Hodgson and McElhinney), New York.

Footnotes
Accepted for publication Nov 22, 1977.

Reprint requests to Department of Surgery, Veterans Aministration Hospital, 130 W Kingsbridge Rd, Bronx, NY 10468 (Dr Hodgson).