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An Alternate Method of Intraoperative Myocardial Protection

Ruel N. Wright, MD; Sidney Levitsky, MD; Kodem S. Rao, MD; Charles Holland, PhD; Harold Feinberg, PhD

Arch Surg. 1978;113(8):976-980.

Abstract
• Potassium-induced cardioplegia was studied in 38 mongrel dogs supported by normothermic cardiopulmonary bypass and subjected to 60 minutes of aortic cross clamping followed by 30 minutes of reperfusion. A study of preischemic and postischemic ventricular function and myocardial high-energy phosphate compounds, lactate, and glycogen showed substantial preservation of high-energy phosphates and ventricular performance when potassium cardioplegia was used. However, the substantial depression in contractility observed following ischemia and reperfusion suggests that potassium cardioplegia alone does not provide adequate intraoperative protection of the myocardium.

(Arch Surg 113:976-980, 1978)

Author Affiliations
From the Departments of Surgery and Pharmacology, Abraham Lincoln School of Medicine and School of Basic Sciences, University of Illinois College of Medicine, Chicago. Dr Wright is a research fellow with The Chicago Heart Association.

Footnotes
Accepted for publication March 28, 1978.

Reprint requests to Department of Surgery, University of Illinois Medical Center, PO Box 6998, Chicago, IL 60680 (Dr Levitsky).

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