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Roy Guinto, MD; Eric G. LeVeen, MD; Moon Ip, MD; Simon Wapnick, MD; Harry H. LeVeen, MD

Arch Surg. 1978;113(9):1096-1099.

Abstract
• The Po₂ was measured in the tissue of the ileal wall of dogs before, during, and up to one hour after reversible occlusion of segmental arteries. The occlusion was then released and the reoxygenation of the bowel wall was observed. Sodium nitroprusside (50 mg in 100 ml of solution) applied topically to the ischemic segment enhanced reoxygenation as compared to control animals. Nitroprusside absorbed into the portal system did not cause hypotension, as is usual with systemic administration, because nitroprusside is inactivated by passage through the liver.

Topically applied sodium nitroprusside alleviates intestinal ischemia by direct local vasodilatation and relaxation of smooth muscle spasm in the ischemic bowel wall. The intraperitoneal use of sodium nitroprusside should be clinically evaluated in situations where visceral perfusion is impaired.

(Arch Surg 113:1096-1099, 1978)

Author Affiliations
From the Departments of Surgery, Veterans Administration Hospital, and Downstate Medical Center, State University of New York, Brooklyn.

Footnotes
Accepted for publication April 17, 1978.

Reprint requests to Veterans Administration Hospital, Brooklyn, NY 11209 (Dr H. LeVeen).

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