This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Nancy L. Ascher, MD; David H. Ahrenholz, MD; Richard L. Simmons, MD; Barbara Weiblen, MS; Lucille Gomez; Leroy A. Forstrom, MD; Mathis P. Frick, MD; Clarence Henke, MD; Jeffrey McCullough, MD

Arch Surg. 1979;114(4):386-392.

Abstract
• We report the results of a new test, indium oxine In 111 scanning, in the diagnosis of postoperative infection. Indium 111 was used to label autologous polymorphonuclear leukocytes, which when reinjected migrate to sites of infection, inflammation, or both. Standard scintigraphy localizes the labeled inflammatory cells at these sites. Sixty-six scans were performed in 43 surgical patients. Thirty-seven scans were categorized as true-positive; 19 scans were categorized as true-negative. Therefore, the accuracy rate was 85%. Two scans (3%) in one patient represented false-positive results. Two scans (3%) were positive for inflammation but there was no infection present; this group was denoted as equivocal. Six scans (9%) were false-negative; false-negative scans are more likely in old lesions with poor blood supply and in areas that overlap regions of normal uptake. The noninvasive nature of the test, high accuracy rate, and ease of administration make it a potentially useful tool in the diagnosis of postoperative infection.

(Arch Surg 114:386-392, 1979)

Author Affiliations
From the Departments of Surgery (Drs Ascher, Ahrenholz, and Simmons); Laboratory Medicine (Ms Weiblen and Dr McCullough); and Radiology (Ms Gomez and Drs Forstrom, Frick, and Henke), University of Minnesota, Minneapolis.

Footnotes
Accepted for publication Dec 18, 1978.

Read before the 86th annual meeting of the Western Surgical Association, Scottsdale, Ariz, Nov 13, 1978.

Reprint requests to Box 110, Mayo Memorial Building, Department of Surgery, University of Minnesota, 412 Union St SE, Minneapolis, MN 55455 (Dr Ascher).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

In vivo imaging of T cell delivery to tumors after adoptive transfer therapy
Pittet et al.
Proc. Natl. Acad. Sci. USA 2007;104:12457-12461.
ABSTRACT | FULL TEXT  

Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug delivery
Gorantla et al.
J. Leukoc. Biol. 2006;80:1165-1174.
ABSTRACT | FULL TEXT  

Gastrointestinal problems in the immunosuppressed patient
AGGARWAL et al.
Arch. Dis. Child. 1998;78:5-8.
FULL TEXT  

Comparison of Indium 111-Labeled Platelets v Leukocytes in a Pyogenic Abscess
Wright et al.
Arch Surg 1985;120:137-141.
ABSTRACT