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Creatinine Clearance in Critically Ill Surgical Patients
Robert F. Wilson, MD;
George Soullier;
David Antonenko, MD, PhD
Arch Surg. 1979;114(4):461-467.
Abstract
• Standard tests of renal function (urine output, BUN, and serum creatinine) were compared with creatinine clearance values and with outcome in 131 critically ill surgical patients. There was a strong negative relationship between creatinine clearance and mortality. Of the 23 patients with a severe reduction of creatinine clearance (<20 mL/min), 17 died. In contrast, 23 of the 24 patients with a creatinine clearance of 100 mL/min or more survived. Urine output, BUN, and serum creatinine levels correlated poorly with creatinine clearance. A urine output of less than 30 mL/hr, a BUN level greater than 40 mg/dL, and a serum creatinine level greater than 2.0 mg/dL in all instances were associated with reduced creatinine clearances. However, more than half of all the patients with a normal urine output, BUN, or serum creatinine levels also had a reduced creatinine clearance.
(Arch Surg 114:461-467, 1979)
Author Affiliations
From the Department of Surgery, Wayne State University School of Medicine and Harper/Grace Hospitals, Detroit.
Footnotes
Accepted for publication Nov 27, 1978.
Read before the 86th annual meeting of the Western Surgical Association, Scottsdale, Ariz, Nov 14, 1978.
Reprint requests to Department of Surgery, Wayne State University School of Medicine, 540 E Canfield St, Detroit MI 48201 (Dr Wilson).
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