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Emphasis on Recent Aspects of Management

Robert P. Davis, MD; Paul F. Nora, MD; Russel G. Kooy, MD; James R. Hines, MD

Arch Surg. 1979;114(4):485-488.

Abstract
• A total of 105 patients with lobular carcinoma of the breast were seen at two hospitals between 1966 and 1978. Mammography was found to be of limited value in the preoperative assessment of these patients. As reported by others, there was a high incidence of bilateral lobular neoplasia. In the patients with lobular carcinoma in situ for whom follow-up data were available, all were alive and well. In contrast to this, infiltrating lobular carcinoma was found to be as malignant a lesion as any other infiltrating breast cancer regardless of the operative procedure performed. These latter tumors were found to bind substantial levels of estrogen receptor proteins. From the information gained, it is suggested that early hormonal manipulation and/or chemotherapy may be advantageous in the patient with recurrent infiltrating lobular carcinoma in particular.

(Arch Surg 114:485-488, 1979)

Author Affiliations
From the Department of Surgery (Drs Davis, Nora, Kooy, and Hines), Northwestern University Medical School, Northwestern Memorial Hospital, and the Department of Surgery (Drs Davis, Nora, and Kooy), Columbus Hospital, Chicago.

Footnotes
Accepted for publication Dec 19, 1978.

Read before the 86th annual meeting of the Western Surgical Association, Scottsdale, Ariz, Nov 14, 1978.

Reprint requests to Chairman, Department of Surgery, Columbus Hospital, 2520 N Lakeview Ave, Chicago, IL 60657 (Dr Nora).

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