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Survival With Individualized Antibiotic Therapy

Lynn D. Solem, MD; Darwin Zaske, PharmD; Richard G. Strate, MD, FACS

Arch Surg. 1979;114(5):580-583.

Abstract
• Five burn patients with ecthyma gangrenosum were treated with gentamicin sulfate in an individualized aminoglycoside regimen. Dosages greater than the currently recommended 3 to 5 mg/kg/day were necessary and ranged from 15 to 30 mg/kg/day. These increased dosages cannot be used routinely but only as serum level data indicate the need. Four of the five patients survived their course of ecthyma gangrenosum. The single fatality received a much smaller dosage of gentamicin as compared with the other four patients. No ototoxic or nephrotoxic reactions were noted in any of the patients.

(Arch Surg 114:580-583, 1979)

Author Affiliations
From the Department of Surgery, (Drs Solem, Zaske, and Strate) School of Medicine and College of Pharmacy (Dr Zaske), St Paul-Ramsey Medical Center, St Paul, and the University of Minnesota, Minneapolis.

Footnotes
Accepted for publication Oct 12, 1978.

Read in part before the ninth annual meeting of the American Burn Association, Anaheim, Cal, March 31, 1977.

Reprint requests to Department of Surgery, St Paul-Ramsey Medical Center, 640 Jackson, St Paul, MN 55101 (Dr Solem).

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ABSTRACT