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Experimental Evaluation in Dogs

Kaichi Isono, MD; Keith A. Kelly, MD

Arch Surg. 1979;114(5):623-627.

Abstract
• In five dogs with Heidenhain pouches, proximal gastric vagotomy and suprapyloric antrectomy did not alter the rate of gastric emptying of 300 mL of 1% dextrose or of 40 plastic spheres, or disrupt the barricade preventing duodenogastric reflux. However, the operation did slow gastric emptying of 50 g of cubed liver and increase the postprandial secretion of hydrochloric acid from the pouch. We concluded that suprapyloric antrectomy can be combined with proximal gastric vagotomy without disturbing the gastric emptying of liquids and indigestible solids or resulting in increased duodenogastric reflux. However, the operation does slow gastric emptying of digestible solids.

(Arch Surg 114:623-627, 1979)

Author Affiliations
From the Department of Surgery, Mayo Medical School, Rochester, Minn. Dr Isono is a visiting scientist from Chiba University, Japan.

Footnotes
Accepted for publication Feb 2, 1979.

Reprint requests to Department of Surgery, Mayo Foundation, Rochester, MN 55901 (Dr Kelly).

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