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Experimental Evaluation by Implantation in the Carotid and Circumflex Coronary Arteries of the Dog

Lester R. Sauvage, MD; Mark W. Walker, MS; Knute Berger, MD; Stephen B. Robel, MS; Michael M. Lischko, MS; Stanley G. Yates, MS; Gordon A. Logan, MD

Arch Surg. 1979;114(6):687-691.

Abstract
• Five types of 4-mm diameter arterial prostheses (three Dacron, one expanded Teflon, one preserved umbilical vein) were studied in the dog to assess graft thrombogenicity. Separate experiments involving six hours of controlled blood flow, one-week carotid implantation, and aortocoronary implantation were performed. In general, graft thrombogenicity derived from controlled flow study was more predictive of a graft's long-term implantation success than were one-week implantation results. In order of increasing thrombogenicity, we ranked grafts studied as follows: noncrimped Dacron, expanded Teflon, crimped Dacron, umbilical vein. Results of 19 experimental left coronary artery implantations using Dacron or Teflon prostheses are reported that indicate grafts with low measured thrombogenicity are most likely to succeed in this site. Data presented in this report suggest there is reason to evaluate noncrimped, kinkresistant, porous Dacron grafts for use both in the left coronary artery and below the knee when there is compelling clinical indication and no autogenous vessels are available.

(Arch Surg 114:687-691, 1979)

Author Affiliations
From the Reconstructive Cardiovascular Research Center International (Drs Sauvage, Berger; Messrs Walker, Lischko, and Yates) and The Heart Center (Dr Logan) of the Providence Medical Center; the Department of Surgery, School of Medicine, University of Washington (Dr Sauvage); and the Department of Mechanical Engineering, Seattle (Wash) University (Mr Robel).

Footnotes
Accepted for publication Nov 9, 1978.

Reprint requests to the Reconstructive Cardiovascular Research Center International, 528-18th Ave, Seattle, WA 98122 (Dr Sauvage).

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