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Immunology, Irradiation, and Lymphocytic Infiltration

James H. Shull, MD; Nehama Sharon, PhD; Thomas A. Victor, MD, PhD; Edward F. Scanlon, MD

Arch Surg. 1979;114(6):729-731.

Abstract
• Patients undergoing thyroidectomies at Evanston (III) Hospital, during a six-month period had immunological studies performed preoperatively. No differential could be found between those with carcinoma or benign pathologic findings. T- and B-cell distribution and lymphocytic response to mitogens varied widely. Quantitative immunoglobulins showed slightly increased levels of IgG in patients with carcinoma and thyroiditis in comparison with those patients with adenomas. Antithyroglobulin antibodies were negative in all patients. Pathology slides from 107 patients with thyroid carcinoma between 1972 and 1978 at Evanston Hospital were reviewed for the presence of thyroiditis, either focal or diffuse. It was found that 50% of all carcinomas had either diffuse or focal thyroiditis. Diffuse thyroiditis was more common in patients with no history of irradiation and papillary carcinoma, and in younger age groups.

(Arch Surg 114:729-731, 1979)

Author Affiliations
From the Departments of Surgery (Drs Shull and Scanlon) and Pathology (Drs Sharon and Victor), Northwestern Medical School, Chicago, and the Evanston Hospital, Evanston, Ill. Dr Shull is a surgical oncology fellow of the American Cancer Society.

Footnotes
Accepted for publication Jan 17, 1979.

Reprint requests to Department of Surgery, Evanston Hospital, 2650 Ridge Ave, Evanston, IL 60201 (Dr Shull).

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