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A Complication of Oral Anticoagulant Therapy

Hadi Dizadji, MD; Richard Hammer; Bernadette Strzyz, MD; John Weisenberger, MD

Arch Surg. 1979;114(6):734-735.

Abstract
• Therapeutic doses of oral anticoagulants have been associated with spontaneous hemorrhage and rupture of apparently normal abdominal viscera. To our knowledge, this is the second reported case of such rupture involving the liver. The patient had sudden severe epigastric pain and signs of acute abdomen and shock. Discrete microscopic changes in the liver may precede massive hemorrhage.

(Arch Surg 114:734-735, 1979)

Author Affiliations
From the Departments of Cardiology (Dr Dizadji) and Pathology (Dr Strzyz) and the Schairer Intensive Care Unit (Dr Weisenberger), Mercy Hospital and Medical Center; and the Departments of Medicine (Dr Dizadji and Mr Hammer) and Pathology (Dr Strzyz), Abraham Lincoln School of Medicine, University of Illinois, Chicago.

Footnotes
Accepted for publication Nov 8, 1978.

Reprint requests to Department of Medicine, Mercy Hospital and Medical Center, Stevenson Expressway at King Dr, Chicago, IL 60616 (Dr Dizadji).

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