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Separate Pancreatic Gastrin Cell and Beta-Cell AdenomasReport of a Patient With Multiple Endocrine Adenomatosis Type 1
J. Tom Peurifoy, MD;
Luis G. Gomez, MD;
James C. Thompson, MD
Arch Surg. 1979;114(8):956-958.
Abstract
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• A patient initially showed symptoms of peptic ulcer disease in 1953 and was later found to have hypercalcemia and hyperparathyroidism. Peptic ulcer symptoms persisted after parathyroidectomy, and results of studies provided evidence of the Zollinger-Ellison syndrome. Evaluation of the patient's family showed a classic pattern of multiple endocrine adenomatosis type 1. The patient underwent total gastrectomy and excision of a gastrin cell adenoma in 1971 with relief of symptoms, but with persistent hypergastrinemia. He remained in good health until January 1976, when symptoms of hypoglycemia developed. Results of laboratory studies were compatible with the diagnosis of a pancreatic beta-cell adenoma. At the time of operation, an adenoma of the head of the pancreas was found. The tumor was excised; no other metastatic tumors were found. The tumor was compatible with a beta-cell adenoma and was found to contain high concentrations of insulin; there was no important amount of gastrin. Symptoms of hypoglycemia have entirely disappeared.
(Arch Surg 114:956-958, 1979)
Author Affiliations
From the Departments of Surgery (Drs Peurifoy and Thompson) and Pathology (Dr Gomez), University of Texas Medical Branch, Galveston.
Footnotes
Accepted for publication Jan 17, 1979.
Reprint requests to Department of Surgery, University of Texas Medical Branch, Galveston, TX 77550 (Dr Thompson).
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