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Luis H. Toledo-Pereyra, MD, PhD; Javier Castellanos, MD; Guillermo Manifacio, MD; Richard C. Lillehei, MD, PhD

Arch Surg. 1979;114(9):1058-1062.

Abstract
• In canine pancreas autografts, more than 20% (30% to 40%) of the pancreatic mass (body and distal head or proximal tail) is required for the establishment of a satisfactory endocrine response. Transplantation of 20% of the pancreatic mass did not result in an adequate restoration of the endocrine function. We believe that this study gives a practical answer to the question of how much pancreatic mass is necessary for the establishment of normal functional response after transplantation. This autotransplantation model precludes the determination of the content and volume of transplanted pancreatic islets. Thus, our model indicates the requirements of the pancreatic mass of the specific anatomic areas that were transplanted, but does not indicate the actual amount of transplanted islets.

(Arch Surg 114:1058-1062, 1979)

Author Affiliations
From the Department of Surgery, Section of Transplantation and Surgical Research, Henry Ford Hospital, Detroit (Dr Toledo-Pereyra), and the Department of Surgery, University of Minnesota, Minneapolis (Drs Castellanos, Manifacio, and Lillehei). Dr Castellanos is now with the Hospital 20 de Noviembre, Mexico, DF, and Dr Manifacio is now with the Instituto Servicio Seguridad Social Trabajadores del Estado Clinic, Cd Juarez, Chihuahua.

Footnotes
Accepted for publication Dec 4, 1978.

Reprint requests to Department of Surgery, Section of Transplantation and Surgical Research, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202 (Dr Toledo-Pereyra).

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