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Michel R. Hurtubise, MD; Joseph C. Bottino, MD; Millie Lawson, RN; Kenneth B. McCredie, MD

Arch Surg. 1980;115(2):212-213.

Abstract
• Thrombotic occlusion remains a major cause of central venous catheter removal prior to completion of therapy. Injection of a dilute solution of a potent fibrinolytic agent, urokinase or streptokinase, into the occluded Silastic central venous catheter consistently reestablishes its patency. This procedure was performed on 352 occluded silicone elastomer central venous catheters with only one failure and one minor complication. We recommend this technique for restoring patency of occluded silicone elastomer central venous catheters.

(Arch Surg 115:212-213, 1980)

Author Affiliations
From the Department of Developmental Therapeutics, University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston. Dr Bottino is now in private practice in New York; Dr Hurtubise is in private practice in Midland, Mich.

Footnotes
Accepted for publication July 25, 1979.

Reprint requests to Department of Developmental Therapeutics, M. D. Anderson Hospital, 6723 Bertner, Houston, TX 77030 (Dr Hurtubise).

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