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Richard A. Becker, MD; Maj George M. Vaughan, MC, USA; Maj Cleon W. Goodwin, Jr, MC, USA; Michael G. Ziegler, MD; Timothy S. Harrison, MD; Arthur D. Mason, Jr, MD; Col Basil A. Pruitt, MC, USA

Arch Surg. 1980;115(4):439-443.

Abstract
• In this prospective study of thyroid catecholamine interactions, 15 severely burned patients were divided into two groups. Nine patients receiving 200 µg/day of triiodothyronine constituted the T₃-treated group. Eight additional patients constituted the untreated group. Mean serum concentrations of T₃ were significantly lower in the untreated group than in the treated group. Mean serum thyroxine (T₄) concentrations were significantly higher in the untreated group than in the treated group. The mean plasma norepinephrine concentration in the untreated group was significantly greater than that of the treated group. In the untreated group, log plasma norepinephrine correlated inversely with serum T₃. Similarly, in the untreated group, log plasma epinephrine correlated inversely with serum T₃. Metabolic rates were not different between groups. These data suggest that a reciprocal relationship exists between plasma concentrations of T₃ and both norepinephrine and epinephrine in untreated burn patients and that treatment with the metabolically active hormone, triiodothyronine, does not alter the level of hypermetabolism accompanying thermal injury.

(Arch Surg 115:439-443, 1980)

Author Affiliations
From the US Army Institute of Surgical Research, Brooke Army Medical Center, Fort Sam Houston, Tex (Drs Becker, Vaughan, Goodwin, Mason, and Pruitt); the University of Texas Medical Branch, Galveston (Dr Ziegler); and the Milton S. Hershey Medical Center, Pennsylvania State University, Hershey (Dr Harrison).

Footnotes
Accepted for publication Nov 29, 1979.

Read before the 87th annual meeting of the Western Surgical Association, Colorado Springs, Colo, Nov 13, 1979.

The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

Reprint requests to Library Branch, US Army Institute of Surgical Research, Brooke Army Medical Center, Fort Sam Houston, TX 78234.

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