Decline in survival after liver transplantation

T. E. Starzl, L. Koep, K. A. Porter, G. P. Schroter, R. Weil 3rd, R. B. Hartley and C. G. Halgrimson

Twenty-three recent cases of orthotopic liver transplantation were individually reviewed in an effort to determine why survival had declined from the 50% one-year survival rate of an immediately precedent series. In the series of 23, only six (26%) achieved one-year survival. Faulty case selection, technical complications, the use of damaged organs, and complications of immunosuppression were the main causes of death. Attention was directed to the possible use of preoperative lymphoid depletion to improve the effectiveness and safety of immunosuppression.