Common bile duct pressure during enflurane anesthesia. Effects of morphine and subsequent naloxone
D. F. Dedrick, W. W. Tanner and F. L. Bushkin
In ten otherwise healthy patients undergoing cholecystectomy and
cholangiography, morphine sulfate, in a dose of 2.5 mg/70 kg body weight,
significantly elevated common bile duct pressure, as measured by water
manometry, two and five minutes after intravenous injection. There was no
added effect from an additional 7.5 mg/70 kg, measured two and five minutes
after injection. Naloxone hydrochloride, in a dose of 1.0 mg/70 kg body
weight, quickly reversed the increase in pressure caused by the morphine.
Radiographic contrast material passed into the duodenum in every patient
after administration of naloxone.
