Glutaraldehyde-tanned ovine collagen conduits as vascular xenografts in dogs: a preliminary report
V. Ketharnathan and B. A. Christie
Collagen tubes grown in sheep around Silastic mandrils were tanned in
neutral, buffered glutaraldehyde and deployed as arterial xenografts in the
aorta of dogs. The grafts maintained patency for up to three years and did
not show any signs of aneurysmal dilation or luminal narrowing. The lumen
became lined with a neointima, and host collagen was deposited around the
periphery so that the thickness of the wall of the graft approximated that
of the aorta.
