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Bruce E. Stabile, MD; Glenn D. Braunstein, MD; Edward Passaro, Jr, MD

Arch Surg. 1980;115(9):1090-1095.

Abstract
• Prior to total gastrectomy, serum levels of gastrin and human chorionic gonadotropin (HCG) and its alpha- and beta-subunits (-HCG and β-HCG) were determined by radioimmunoassays in 40 patients with the Zollinger-Ellison syndrome. Basal serum gastrin levels greater than 1,500 pg/mL were found only in patients with metastases to lymph nodes or liver, while levels greater than 8,000 indicated massive liver replacement by tumor. Gastrin levels less than 1,500 pg/mL had no correlation with malignant behavior. Neither the calcium-infusion nor secretin-injection test was useful in identifying tumors as benign or malignant. Basal serum levels of -HCG were elevated (> 7 ng/mL) in four of 20 patients with metastatic gastrinoma and were normal in all 16 patients with benign disease. There was a significant correlation between basal gastrin and -HCG levels in patients with malignant gastrinoma but not for those with benign tumors. The results suggest that serum gastrin and -HCG levels can be useful in assessing the biologic behavior of gastrinomas and in planning appropriate surgical and nonsurgical treatment.

(Arch Surg 115:1090-1095, 1980)

Author Affiliations
From the General Surgery Service, Veterans Administration Wadsworth Medical Center (Drs Stabile and Passaro); the Departments of Surgery (Drs Stabile and Passaro) and Medicine (Dr Braunstein), UCLA School of Medicine; and the Endocrinology Section, Department of Medicine, Cedars-Sinai Medical Center (Dr Braunstein), Los Angeles.

Footnotes
Accepted for publication May 7, 1980.

Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Rancho Mirage, Calif, Jan 19, 1980.

Reprint requests to Surgical Service (691/112K3), VA Wadsworth Medical Center, Wilshire and Sawtelle Blvd, Los Angeles, CA 90073 (Dr Stabile).

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