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Wesley S. Moore, MD; Milos Chvapil, MD; George Seiffert, MD; Ken Keown, MA

Arch Surg. 1981;116(11):1403-1407.

Abstract
• To develop an infection-resistant arterial prosthesis, amikacin was bonded to 6-mm, uncrimped, filamentous velour prostheses using a collagen-release system. Infrarenal abdominal aortas were resected in 26 mongrel dogs. Thirteen dogs had their aortas replaced with the antibiotic-bonded grafts and 13 dogs had their aortas replaced with a graft containing collagen without antibiotics. Following closure of the abdominal incision, each dog received an intravenous infusion of 10⁸ organisms of Staphylococcus aureus administered over a 30-minute interval. Three weeks after recovery from operation, the grafts were removed under aseptic conditions; all 13 (100%) of the control grafts were infected, but only one of 12 experimental grafts (8%) was infected. There were no adverse healing effects; to the contrary, there appeared to be accelerated development of a cellular neointima and fibroblastic infiltration to the interstices. Antibiotic bonding with a collagen-release system is a promising method for imparting infection resistance to a vascular prosthesis.

(Arch Surg 1981;116:1403-1407)

Author Affiliations
From the Department of Surgery, UCLA Center for the Health Sciences, Wadsworth Veterans Administration Medical Center, Los Angeles (Drs Moore and Seiffert and Mr Keown); and the University of Arizona Health Science Center, Tucson (Dr Chvapil).

Footnotes
Accepted for publication July 13, 1981.

Read at the 29th scientific meeting of the International Cardiovascular Society, Dallas, June 11, 1981.

Reprint requests to Section of Vascular Surgery, Center for the Health Sciences, University of California, Los Angeles, CA 90024 (Dr Moore).

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