 |
|
Heparin-Induced Thrombocytopenia With Thrombosis and Hemorrhage
Donald Kapsch, MD;
Donald Silver, MD
Arch Surg. 1981;116(11):1423-1427.
Abstract
| |
• Thrombocytopenia (platelet count, 5,000 to 96,000/cu mm; average platelet count, 48,000/cu mm) developed in 31 patients while they were receiving prophylactic or therapeutic heparin sodium therapy. Twenty-one of these patients had associated thromboembolic complications that contributed to the deaths of eight patients. Twelve arterial thromboembolectomies were required for limb preservation in eight patients, with seven arterial thrombolectomies, early in the series, failing because heparin therapy was continued in the postoperative period. Coagulation tests failed to identify a consumptive coagulopathy as the cause of the thrombocytopenia. Cessation of heparin administration was associated with avoidance or remission of the thromboembolic complications and immediate improvement of the thrombocytopenia. Platelet count monitoring during heparin therapy remains the most effective means for the identification of this disorder before the development of the thromboembolic complications.
(Arch Surg 1981;116:1423-1427)
Author Affiliations
From the Department of Surgery, University of Missouri-Columbia Health Sciences Center.
Footnotes
Accepted for publication July 7, 1981.
Read at the 29th scientific meeting of the International Cardiovascular Society, Dallas, June 11, 1981.
Reprint requests to Department of Surgery, University of Missouri-Columbia Health Sciences Center, 807 Stadium Blvd, Columbia, MO 65212 (Dr Silver).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
A statistical analysis of factors predisposing patients to heparin resistance
Chan et al.
Perfusion 2006;21:99-103.
ABSTRACT
Heparin-Induced Thrombocytopenia
Sobel
PERSPECT VASC SURG ENDOVASC THER 1992;5:1-27.
Heparin-Associated Thrombocytopenia
BURNAKIS
ANN INTERN MED 1984;101:279-280.
ABSTRACT
|
