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Agostino Molteni, MD, PhD; Raymond L. Warpeha, MD, PhD; Loredana Brizio-Molteni, MD; Ellen M. Fors, MS

Arch Surg. 1981;116(2):207-210.

Abstract
• Estradiol (E₂) receptor-binding protein was measured in 42 neoplasms and normal tissues from the head and neck region. Tissues with high E₂ receptor protein content included normal skin and normal mucosa of the nose and the floor of the mouth and of the parotid and submandibular salivary glands. Two of four papillary carcinomas of the thyroid, three of five pleomorphic adenomas of the parotid, four of six squamous cell carcinomas of the oral cavity, one angiofibroma of the nose, and an eye (sclera) melanoma also had a high content of E₂-binding protein. The demonstration of estrogen receptors in these neoplasms may indicate that these tumors also, as many breast lesions, may be hormone-dependent. If this is correct, an appropriate hormonal treatment may influence their biological evolution.

(Arch Surg 116:207-210, 1981)

Author Affiliations
From the Department of Pathology, Northwestern University School of Medicine, Chicago (Dr Molteni and Ms Fors), and the Division of Plastic Surgery, Department of Surgery, Loyola University, Stritch School of Medicine, Maywood, Ill (Drs Warpeha and Brizio-Molteni).

Footnotes
Accepted for publication July 14, 1980.

Reprint requests to Department of Pathology, Northwestern University School of Medicine, 303 E Chicago Ave, Chicago, IL 60611 (Dr Molteni).

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