Estradiol receptor-binding protein in head and neck neoplastic and normal tissue
A. Molteni, R. L. Warpeha, L. Brizio-Molteni and E. M. Fors
Estradiol (E2) receptor-binding protein was measured in 42 neoplasms and
normal tissues from the head and neck region. Tissues with high E2 receptor
protein content included normal skin and normal mucosa of the nose and the
floor of the mouth and of the parotid and submandibular salivary glands.
Two of four papillary carcinomas of the thyroid, three of five pleomorphic
adenomas of the parotid, four of six squamous cell carcinomas of the oral
cavity, one of angiofibroma of the nose, and an eye (sclera) melanoma also
had a high content of E2-binding protein. The demonstration of estrogen
receptors in these neoplasms may indicate that these tumors also, as many
breast lesions, may be hormone-dependent. If this is correct, an
appropriate hormonal treatment may influence their biological evolution.
